In vitro and ex vivo antiplasmodial activity of 1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one) against circulating strains of Plasmodium spp. in the state of Rondônia, Brazil

Malaria is a disease caused by Plasmodium spp. protozoa. The ability of to develop resistance current antimalarial drugs makes the study chemotherapeutic alternatives extremely important. This aimed evaluate activity compound 3286938 (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one), which presents in its structure 3,4,5-trimethoxyphenyl group, vitro, using W2 strain P. falciparum and against circulating strains vivax from state Rondônia. obtained an IC50 24.4 µM falciparum, strains, it presented median (MD)=38.7 for MD=6.7 falciparum. As toxicity, showed CC50 > 500 VERO HepG2 with selectivity index greater than 12.9, ratio calculated regarding Vero cells. was not considered hemolytic vitro assays, thus indicating specificity antiplasmodial action. Based on results presented, considering unprecedented character compound, can be concluded that shown promising complementary vivo studies aiming produce effective